Patients with acne had a significantly higher family history of acne compared to controls (P=0.006). Serum level of malondialdehyde was significantly higher in cases (P=0.01), while high-density lipoprotein cholesterol was significantly lower (P=0.02). Moreover, significantly lower fiber intake was observed in cases compared with controls (P=0.007).
Moazen, M., Mazloom, Z., Jowkar, F., Nasimi, N., & Moein, Z. (2019). Vitamin D, Adiponectin, Oxidative Stress, Lipid Profile, and Nutrient Intakes in the Females with Acne Vulgaris: A Case-Control Study. Galen medical journal, 8, e1515. https://doi.org/10.31661/gmj.v8i0.1515
Psyllium supplementation improves skin condition, overall health, and quality of life in patients with celiac disease undergoing systemic therapy for moderate acne.
Ledentsova, S., Gulyaev, N., Sitkin, S., & Seliverstov, P. (2021). Acne as a common extraintestinal manifestation of celiac disease. Treatment approaches. Meditsinskiy sovet = Medical Council. https://doi.org/10.21518/2079-701x-2020-21-126-135.
Psyllium supplementation in addition to antibiotic and systemic retinoid treatment improves skin health, intestinal microbiome, general well-being, and quality of life in patients with celiac disease having moderate acne.
Ledentsova, S., Gulyaev, N., Oreshko, L., & Seliverstov, P. (2023). Microbiome changes in acne patients with celiac disease under different treatments. Experimental and Clinical Gastroenterology. https://doi.org/10.31146/1682-8658-ecg-207-11-70-79.
Dall'Oglio, F., Milani, M., & Micali, G. (2018). Effects of oral supplementation with FOS and GOS prebiotics in women with adult acne: the "S.O. Sweet" study: a proof-of-concept pilot trial. Clinical, cosmetic and investigational dermatology, 11, 445–449. https://doi.org/10.2147/CCID.S179627(edited)
Chipchanged the channel name: Prebiotic fiber for acne6/07/2024 7:51 PM
Kazandjieva J, Dimitrova J, Sankeva M, Yankov D, Bocheva V, Kircheva K, Gincheva V, Gospodinova K, Andasorova R, Milanova M, Jeleva D, Zlateva P, Vasileva I, Yankova R, Gotseva S, Dakova T, Zografova E, Marina S, Kateva M, Broshtilova V, Todeva V, Tsankov N, Mitova Z, Boyanova N, Milani M. Efficacy of a retinoid complex plus anti-inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor-blinded, parallel-group, multicenter trial on 184 women. J Cosmet Dermatol. 2022 Nov;21(11):5716-5722. doi: 10.1111/jocd.15074. Epub 2022 May 23. PMID: 35545875.
Limitations: Food supplement containing a mixture of prebiotic molecules (FOS&GOS) zinc, lactoferrin, and niacinamide, not just one ingredient
# Topical Glucomannan hydrolysates (GMH)
"The results showed that there was a significant (P< 0.001) improvement of the skin health at the second (20 days) and third clinical evaluation (40 days) for established (e.g. antibiotics) and GMH treatments."
Bateni, Ellie, et al. "The use of konjac glucomannan hydrolysates (GMH) to improve the health of the skin and reduce acne vulgaris." American Journal of Dermatology and Venereology 2.2 (2013): 10-14.
Potential side effects:
Can cause gas, bloating, and digestive discomfort, especially when started at high doses (depending on the prebiotic fiber type)
May interfere with absorption of certain medications and nutrients.
